Slide 2 of 5 of Coagulación sanguínea. VÍA EXTRÍNSECA; 2. Vía Intrínseca; 3. Conversión de la Vías y cascada de la coagulación. Enzimas que actuan en la coagulación.c. Asignatura: .. Al final, las vías intrínse cas y extrínsecas confluyen en una secuencia de etapas en común. hasta. Los factores de la coagulación de la vía extrínseca se activan al producirse el La coagulación también puede activarse por la vía intrínseca al entrar en.
|Published (Last):||10 May 2008|
|PDF File Size:||19.37 Mb|
|ePub File Size:||13.67 Mb|
|Price:||Free* [*Free Regsitration Required]|
Consultado el 7 de abril de Structure of a fucose-branched chondroitin sulfate from sea cucumber.
Tissue factor pathway inhibitor. Anticoagulant activity in extracts of British marine algae.
Archivado desde el original el 16 de abril de Recently, a group of scientists had stand out the potentiality of some proteins and proteoglycans capable of interfere with blood clotting cascade, particularly from Codium Matsubara et al. A fibrinolytic enzyme from a marine green alga, Codium latum.
Factor de coagulación XI
The results showed other algae with slightly inhibition of clot formation activity, it is not common to consider this species for further investigation, nevertheless the retardation of formation of clot by Penicillus capitatusa species evolutionary related to Halimeda genus Vroom et al. Chemical structure of antithrombin-active Rhamnan sulfate from Monostroma cazcada.
Standardized plasma exgrinseca tests thrombin and prothrombin time were used. It has been reported also that brown algae have a potent anticoagulant activity in fucoidans Chevolot et al. It is known that species of Chlorophyta synthesized polydisperse heteropolysaccarides with low sulfate content, glucoronoxilorhamans, glucoronoxilorhamagalactans and xyloarabinogalactans, some of them with a potent anticoagulant activity Uehara et al.
Cytogenetics and Cell Genetics 52 Other seven species presented a slightly anticoagulant activity. Blood coagulation and haemostasis. Further data on the structure of brown seaweed fucans: Inhibition of thrombin by sulfated polysaccharides isolated from green algae.
Purification and intrinsecx of a fibrinolytic enzyme and identification of fibrinogen clotting enzyme in a marine green alga Codium divaricatum. In the laboratory the material was thawed at room temperature and a fraction of this czscada preserved in glycerinated formaldehyde for species determination and Voucher organisms, this specimens were kept in our laboratory as internal reference material.
We can suggest these four species as a sources of new anticoagulant substances. These molecules have different degree of sulfate in their structure and therefore are capable of substitute heparin Farias et al.
The mixture was homogenized in a Waring blender, centrifuged at x g for 15 minutes and supernatant filtered through 0. Human plasma was obtained by venous puncture with a disposable syringe, blood was combined with 3.
The results showed that four species presented potent anticoagulant activity same as heparin in the two pathways: The research effort has been focused on one genus, forgotten the basic detection of different algae extrineeca a potential source of alternative anticoagulant molecules.
Structure and anticoagulant activity of a fucosylated chondroitin sulfate from echinoderm. Vistas Leer Editar Ver historial.
Detección de sustancias anticoagulantes en algunas macroalgas marinas
We also detected a variation in the anticoagulant potency, a change in the anticoagulant activity related with the intrinsic or extrinsic pathways of coagulation or even the disappearance of the extrinseac activity in both test of Caulerpa cupressoidesC. It is not common that extracts from algae were active in both tests, in the literature are only few examples as Codium fragile subsp.
British Journal of Haematology 90 4: The Hague, The Netherlands. Epiphytes were removed carefully from the algae under the microscope to avoid contamination.
Factor de coagulación XI – Wikipedia, la enciclopedia libre
SPB Academic Publishing bv. The discovery of alternative anticoagulant molecules must be an important task for scientists. De Wikipedia, la enciclopedia libre. Revista de la Sociedad Mexicana de Historia Natural An International Journal in Haemostasis and Thrombosis 16 4: Thrombosis and Haemostasis 86 1: Agardh, Caulerpa cupressoides West in Vahl C.
The extracts could act preventing the conversion of prothrombin to thrombin, also they could act stopping the transformation of fibrinogen to convert it to fibrin o even in the polymerization of this last molecule.