Kidney Stones >; Tamsulosin Ineffective for Small Ureteral Stones In the double-blind STONE (Study of Tamsulosin for Urolithiasis in the. Nephrolithiasis specifically refers to calculi in the kidneys, but renal selective blockers, such as tamsulosin, also relax the musculature of the. Medscape – Benign prostatic hyperplasia-specific dosing for Flomax (tamsulosin), frequency-based adverse effects, comprehensive interactions.

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Feel free to contribute! Both tamsulosin and nifedipine significantly reduced the need for diclofenac when compared with the nephrolithiaasis group.

This could potentially reduce ED revisits, reduce the number of invasive procedures and make happy patients. Kaneko T et al. In the absence of robust or even decent evidence, we should not be using this medication for ED patients presenting with renal colic. These advances include shock wave lithotripsy SWLureteroscopy, and percutaneous nephrostolithotomy.

This was a true RDCT. Yilmaz E et al In a more recent prospective study, De Sio and associates 20 showed similar results. Alpha blockers for treatment of ureteric stones: All of these RCTs showed a benefit and were not mentioned in the audio report. Both meta analysis had positive findings vlomax favor of the use of Tamsulosin. In the control group, only Alpha-blockers promote stone passage in patients receiving shock wave lithotripsy, and may be able to relieve ureteral stent-related symptoms.

The best evidence we have to date, does not show a significant benefit in the use of tamsulosin in renal colic to facilitate stone passage. Interestingly, they found that in 4 patients receiving phentolamine, their renal obstruction was corrected, as depicted by intravenous pyelography, as was their pain.


Leave nephrollthiasis Reply Cancel reply Your email address will not be published. The systematic review data from the Lancet and Ann of EM in are minimally, if at all, useful. Find us on iTunes!

Latest posts by Anand Swaminathan see all. The percentage of stones passed was significantly greater in the group receiving tamsulosin Nifedipine versus tamsulosin for the management of lower ureteral stones. A double-blind comparison with placebo. Dellabella and colleagues 18 evaluated 60 patients with symptomatic ureterovesical junction stones.

For over a decade, calcium channel blockers i. Summary Alphaadrenergic receptors are located throughout the human ureter. At the European Association of Urology Congress in Copenhagen, Denmark, researchers reported on a study showing that tamsulosin did not improve the rate of spontaneous stone passage SSP among patients with acute ureteric colic.

These interventions were mostly based on poor methodologic studies and meta-analyses of these flawed studies Hollingsworth I discussed this issue on EMRAP back in December and received the following comments from one of the listeners who discussed this topic with their urology group.

The time to expulsion was significantly less with tamsulosin: The time to passage was also not significantly different. Tamsulosin has been studied as an adjunct therapy along with SWL. Effect of tamsulosin on passage of symptomatic ureteral stones.

Mean stone size was small 3.

The Use of Alpha-Blockers for the Treatment of Nephrolithiasis

The most important factors in predicting the likelihood of spontaneous stone passage are stone location and stone size. Both tamsulosin and nifedipine significantly increased stone passage rates.

This article has been cited by other articles in PMC. Patients were randomized after stent placement to receive either alfuzosin 10 mg daily or placebo for 4 weeks. Please review our privacy policy. The majority of stones will pass spontaneously i. Author information Copyright and License information Disclaimer. There were minimal side effects reported from the tamsulosin, and none of the patients had to stop taking tamsulosin secondary to a side effect.


I question is applicability to stones between 4 and 10mm. Patients discharged on parenteral diclofenac not standard care for us This flmax the only randomized trial to show a benefit to tamsulosin but there are some major issues.

Adrenergic innervation of the ureter.

Alphaadrenergic receptor antagonists have some degree of selectivity for the detrusor and the distal glomax and have therefore been the next agents investigated for their potential to promote stone expulsion and decrease pain. They compared 2 groups of 30 patients each: Until such time, I think for any ureteric stone between mm, Flomax is useful.

Tamsulosin Ineffective for Small Ureteral Stones – Renal and Urology News

There will be continued conjecture that larger stones may benefit due to inconsistency in the literature and the absence of a RDCT primarily looking at passage flomaz larger stones.

A Randomized Clinical Trial. The median time in hours to stone passage was 72 hours for the group receiving tamsulosin, and this was significantly less than the hours for the groups receiving nifedipine or phloroglucinol.

Between and there were four more small, RCTs looking at the issue.